Human trafficking is a grave issue affecting U.S. cities in varying degrees. Cities with the highest reported cases include Atlanta, Houston, and Las Vegas, where factors like population density, transportation hubs, and socioeconomic disparities contribute to vulnerability. These urban centers often serve as hotspots for both sex and labor trafficking. In contrast, cities with relatively lower reported cases include Portland, Seattle, and Minneapolis, where community awareness, effective law enforcement, and social support systems play significant roles in mitigating trafficking risks. Nonetheless, combating human trafficking requires a comprehensive nationwide effort to address root causes and implement stringent measures against this heinous crime.